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Inhibition of growth and motility of human A549 lung carcinoma cells by a recombined vascular basement membrane derived peptide

โœ Scribed by Cheng-kun Wang; Jian-guo Cao; Bo Peng; Yi-xue Gu; Guo-pei Zheng; Zhi-min He


Book ID
116335409
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
549 KB
Volume
292
Category
Article
ISSN
0304-3835

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I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine