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Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis

โœ Scribed by Manisha Ray; Daniel R. Hostetter; Carly R.K. Loeb; Jeffry Simko; Charles S. Craik

Book ID
112179563
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
820 KB
Volume
72
Category
Article
ISSN
0270-4137

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## Abstract Bone morphogenetic proteins (BMPs) have long been implicated in the process of prostate cancer progression and bone metastasis. This current study investigates the role of GDFโ€9, a BMP member, in prostate cancer. GDFโ€9 was overโ€expressed in PCโ€3 cells using a mammalian expression constr