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cAMP Protection of Pancreatic Cancer Cells against Apoptosis Induced by ERK Inhibition

✍ Scribed by Marie-Josée Boucher; Cathia Duchesne; Jean Lainé; Jean Morisset; Nathalie Rivard


Book ID
115588210
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
286 KB
Volume
285
Category
Article
ISSN
0006-291X

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Pancreatic cancer cells are usually resistant to apoptosis induced by cytotoxic drugs, by activation of surface receptors such as Fas and TNF receptor or by serum or growth factor withdrawal. Actinomycin D (actD) is an inhibitor of RNA synthesis and acts as a potent inducer of apoptosis in several c