Retinoic acid inhibits expression of TNF
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S. Thameem Dheen; Yan Jun; Zhou Yan; Samuel S.W. Tay; Eng Ang Ling
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Article
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2005
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John Wiley and Sons
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English
⚖ 904 KB
The release of proinflammatory mediators such as tumor necrosis factor-␣ (TNF-␣) and nitric oxide by microglia has been implicated in neurotoxicity in chronic neurodegenerative diseases such as Alzheimer's disease. As all-trans-retinoic acid (RA) has been reported to exert anti-inflammatory actions