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Inhibition of superoxide production and chemotaxis by methotrexate in neutrophils primed by TNF-α or LPS

✍ Scribed by Akiro Okuda; Masaru Kubota; Kenichiro Watanabe; Machiko Sawada; Seiji Koishi; Akihiro Kataoka; Ikuya Usami; Ying Wei Lin; Kenshi Furusho


Book ID
114792270
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
545 KB
Volume
59
Category
Article
ISSN
0902-4441

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Methotrexate inhibits superoxide product
✍ Akiro Okuda; Masaru Kubota; Machiko Sawada; Seiji Koishi; Akihiro Kataoka; Rikim 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 933 KB

Treatment of circulating human neutrophils with recombinant human granulocyte colony-stimulating factor (rhG-CSF) for 30 min augmented superoxide generation and chemotaxis induced by N-formylmethionyl-leucyl-phenylalanine (fMLP) in a dose dependent manner. When neutrophils were treated with 1 pM of