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Inhibition of Gap Junctional Intercellular Communication by Toxic Metals

✍ Scribed by Vinken, Mathieu; Ceelen, Liesbeth; Vanhaecke, Tamara; Rogiers, Vera


Book ID
120978790
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
951 KB
Volume
23
Category
Article
ISSN
0893-228X

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## Abstract The phorbol ester, 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA), is a potent inhibitor of gap junctional intercellular communication (GJIC). This inhibition requires activation of protein kinase C (PKC), but the events downstream of this kinase are not known. Since PKC can activate ex