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Inhibition of fibril formation and toxicity of a fragment of α-synuclein by an N-methylated peptide analogue

✍ Scribed by Angela M. Bodles; Omar M.A. El-Agnaf; Brett Greer; David J.S. Guthrie; G.Brent Irvine


Book ID
116766392
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
205 KB
Volume
359
Category
Article
ISSN
0304-3940

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## Abstract Abnormal protein aggregation in the brain is linked to the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Recent studies revealed that the oligomeric form of aggregates is most likely the toxic species, and thus could be a go