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Inhibition of Exportin-1 inhibits endothelial cell ICAM expression

✍ Scribed by Mark D. Walsh; Anirban Banerjee; Christine Hamiel; Katherine Barsness; Robert McIntyre


Book ID
113675985
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
53 KB
Volume
199
Category
Article
ISSN
1072-7515

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Endothelial cells, as they normally exist in the vasculature as quiescent cells, perform several functions. In an inflammatory response, endothelial cells are activated to up-regulate a number of genes, including E-selectin (ELAM-l), VCAM-1, ICAM-1, interleukin (IL)-l, IL-8 and plasminogen activator