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Inhibition of epidermal growth factor binding to Swiss 3T3 cells by human platelet release-products

โœ Scribed by Kenneth D. Brown; Diane M. Blakeley; Moira MacDonald

Book ID
112491698
Publisher
Springer
Year
1983
Tongue
English
Weight
430 KB
Volume
3
Category
Article
ISSN
0144-8463

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Modulation of the epidermal growth facto
Modulation of the epidermal growth factor receptor by brain-derived growth factor in Swiss mouse 3T3 cells
โœ Shuan Shian Huang; Vinata B. Lokeshwar; Jung San Huang ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 721 KB

Incubation of Swiss mouse 3T3 cells at 37ยฐC with bovine brain-derived growth factor (BDGF) decreased the cell surface '251-EGF binding activity of these cells by 70-80%. This down-modulation of the EGF receptor by BDGF was time, temperature, and dose dependent. Scatchard plot analysis indicated that