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Inhibition of EGF receptor tyrosine kinase attenuates the mitogenic effect of EGF, IGF-1 and serum in an intestinal cell line

Book ID: 123046652
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 162 KB
Volume: 108
Category: Article
ISSN: 0016-5085
DOI: 10.1016/0016-5085(95)27299-2

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## Abstract High expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of squamous‐cell carcinomas of head and neck (SCCHN). ZD1839 (‘Iressa’) is an orally active, selective EGFR‐TKI (EGFR‐tyrosine kinase inhibitor) that blocks signal transduction pathways