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Inhibition of drug metabolism by the antimalarial drugs chloroquine and primaquine in the rat

โœ Scribed by David J. Back; Harpal S. Purba; Christoph Staiger; Michael L'E. Orme; Alasdair M. Breckenridge


Book ID
115777177
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
426 KB
Volume
32
Category
Article
ISSN
0006-2952

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Advances made over the last decade indicate that the mechanism of action of important antimalarial agents, such as chloroquine, involves formation of p -p complexes between drugs and ferriprotoporphyrin IX. This process is believed to block the detoxification of host haemoglobin-derived haem in the