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Inhibition of drug binding to human serum albumin by cholecystographic agents

✍ Scribed by Carlo Bertucci; Samanta Cimitan


Book ID
114019266
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
659 KB
Volume
58
Category
Article
ISSN
0014-827X

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Binding sites on human serum albumin (HSA) for anionic drugs and fatty acids have been thermodynamically characterized by microcalorimetry. The binding and the thermodynamic parameters were directly computed from the calorimetric titration data at 37 "C in a phosphate buffer (pH 7.4) using one-and t