Binding of Anti-HIV Drugs to Human Serum Albumin
β Scribed by Alessio Bocedi; Stefania Notaril; Pasquale Narciso; Alessandro Bolli; Mauro Fasano; Paolo Ascenzi
- Book ID
- 111741558
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 330 KB
- Volume
- 56
- Category
- Article
- ISSN
- 1521-6543
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π SIMILAR VOLUMES
The binding of representative chemical classes of nonsteroidal anti-inflammatory drugs (NSAIDs) to human serum albumin (HSA) was investigated by equilibrium dialysis. Warfarin enantiomers were used as specific markers in displacement studies. Data were analyzed by a computerized nonlinear least squa
Binding of drugs to plasma proteins is an important determinant for their efficacy because it modulates drug availability to the intended target. Co-administered drugs may bind to the same protein site or to different functionally linked clefts following competitive and allosteric mechanisms. Here,