Enzymatic Hydroxylation by Dopamine β-Hy
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Anton A. Mitrochkine; Frank Eydoux; Gérard Gil; Marius Réglier
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Article
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1998
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John Wiley and Sons
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English
⚖ 598 KB
## O-O activation / C-H activation The three-dimensional aspects of the chemistry of dopamine β-hydroxylase (DBH) was studied through a conformationally-restricted substrate analog approach. We found that the DBH-catalyzed hydroxylation of 2-aminoindane (1) exclusively produced the trans-(1S,2S)-2-