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Inhibition of DNA Synthesis in Ehrlich Ascites Cells by Actinomycin D, I. Delayed Inhibition by Low Doses

โœ Scribed by Renato Baserga, Richard D. Estensen, Robert O. Petersen and John P. Layde


Book ID
123658135
Publisher
National Academy of Sciences
Year
1965
Tongue
English
Weight
277 KB
Volume
54
Category
Article
ISSN
0027-8424

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Delayed inhibition of DNA synthesis in m
โœ Renato Baserga; Richard D. Estensen; Robert O. Petersen ๐Ÿ“‚ Article ๐Ÿ“… 1966 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 737 KB

Actinomycin D (0.008 pg/gm of body weight) injected intraperitoneally every two hours, produced a prompt 50% inhibition of RNA synthesis in the jejunum of mice, and a delayed inhibition of DNA synthesis, that reached its maximum inhibition (68% of control values) 4.5 hours after the first injection