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Inhibition of DNA Adduct Formation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Dietary Indole-3-carbinol (I3C) in the Mammary Gland, Colon, and Liver of the Female F-344 Rat

✍ Scribed by HERMAN A. J. SCHUT; RODERICK H. DASHWOOD


Book ID
119871362
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
442 KB
Volume
768
Category
Article
ISSN
0890-6564

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Chemopreventive properties of Indole-3-C
✍ Ying-Hui He; Maarten H.E. Smale; Herman A.J. Schut πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 164 KB πŸ‘ 2 views

Indole-3-carbinol (I3C), a naturally occurring inhibitor of experimental carcinogenesis, was evaluated for its possible inhibitory effect on DNA-adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary mutagen, in female F344 rats. PhIP is a mammary carcinogen in female

Inhibition of DNA adduct formation of 2-
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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3