## Abstract 2βaminoβ1βmethylβ6βphenylimidazo[4,5β__b__]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIPβDNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed
Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats
β Scribed by Madhu Purewal; Adrian J Fretland; Herman A.J Schut; David W Hein; Michael J Wargovich
- Book ID
- 117469700
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 106 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0304-3835
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Indole-3-carbinol (I3C), a naturally occurring inhibitor of experimental carcinogenesis, was evaluated for its possible inhibitory effect on DNA-adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary mutagen, in female F344 rats. PhIP is a mammary carcinogen in female
2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3