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Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate cancer cells in vitro

✍ Scribed by Petra Anna Ohneseit; Guido Krebiehl; Klaus Dittmann; Rainer Kehlbach; Hans Peter Rodemann


Book ID
118496820
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
720 KB
Volume
82
Category
Article
ISSN
0167-8140

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Cyclooxygenase-2 inhibitor celecoxib aug
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## Abstract Many tumors constitutively express high levels of the inducible form of proinflammatory enzyme, cyclooxygenase‐2 (COX‐2). Increased COX‐2 expression is associated with tumor cell resistance to many cytotoxic chemotherapy drugs. Furthermore, increased resistance to cytotoxic antitumor dr