Inhibition of Cyclic 3′,5′-AMP Phosphodiesterase in Islet Cells and Other Tissues by Tolbutamide
✍ Scribed by GOLDFINE, IRA D.; PERLMAN, ROBERT; ROTH, JESSE
- Book ID
- 109679878
- Publisher
- Nature Publishing Group
- Year
- 1971
- Tongue
- English
- Weight
- 426 KB
- Volume
- 234
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/234295a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Treatment of NIH 3T3 cells with adenylate cyclase activator adrenaline (10(-6) M) or cAMP phosphodiesterase inhibitor theophylline (10(-3) M) was shown to lead to intracellular cAMP elevation followed by a 2.0-to 2.5-fold increase in the 2',5'-oligoadenylate synthetase activity. This process was blo
## Abstract The three xanthine derivatives, caffeine, theophylline and 3‐isobutyl‐1‐methyl‐xanthine (IBMX) produced dose‐dependent increases in cyclic AMP concentrations in HeLa cells after long term treatment. Only IBMX produced increases over the first 60 minutes, with a peak of approximately 5‐f
## Abstract The effects of DBcAMP in doses from 1.5 × 10^−8^ to 1.5 × 10^−3^ M on the compartmental apparent surface area (ASA) and (5‐^3^H)uridine radioactivity concentration (URC), (methyl‐^3^H)thymidine labelling index per 1 hour ([__Me__‐^3^H]Tdr LI/h) and per cent mitotic index (MI%) and colch