Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
β Scribed by Mitsuru Futakuchi; Jing Lei Cheng; Masao Hirose; Naoya Kimoto; Young-Man Cho; Toshio Iwata; Masaaki Kasai; Shinkan Tokudome; Tomoyuki Shirai
- Book ID
- 117467253
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 115 KB
- Volume
- 178
- Category
- Article
- ISSN
- 0304-3835
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## Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-blpyridine (PhlP). Examination of 62 microsatellite loci revealed M I in nine of 15 (60%) PhlP-induced mammary
## Abstract 2βAminoβ1βmethylβ6βphenylimidazo[4,5β__b__]pyridine(PhlP) is the most abundant of the heterocyclic amines, a group of potent carcinogens contained in cooked meat and fish. Female F344 rats fed a diet containing 100 or 400 ppm PhIP developed mammary carcinomas within 104 or 52 wk, respec