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Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

✍ Scribed by Mitsuru Futakuchi; Jing Lei Cheng; Masao Hirose; Naoya Kimoto; Young-Man Cho; Toshio Iwata; Masaaki Kasai; Shinkan Tokudome; Tomoyuki Shirai


Book ID
117467253
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
115 KB
Volume
178
Category
Article
ISSN
0304-3835

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## Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-blpyridine (PhlP). Examination of 62 microsatellite loci revealed M I in nine of 15 (60%) PhlP-induced mammary

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## Abstract 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine(PhlP) is the most abundant of the heterocyclic amines, a group of potent carcinogens contained in cooked meat and fish. Female F344 rats fed a diet containing 100 or 400 ppm PhIP developed mammary carcinomas within 104 or 52 wk, respec