Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids
✍ Scribed by R. Edenharder; H. Krieg; V. Köttgen; K.L. Platt
- Book ID
- 117767127
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 129 KB
- Volume
- 537
- Category
- Article
- ISSN
- 1383-5718
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Chlorophyllin (CHL), a water soluble derivative of the green pigment chlorophyll, was evaluated for its antimutagenic activity towards benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). CHL suppressed dose-dependently the formation of 8-azaguanine-resistant mutant colonies in Salmonella typhimurium
## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino