Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol
โ Scribed by Jamal M Arif; C.Gary Gairola; Gary J Kelloff; Ronald A Lubet; Ramesh C Gupta
- Book ID
- 114070180
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 421 KB
- Volume
- 452
- Category
- Article
- ISSN
- 0027-5107
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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
Indole-3-carbinol (I3C), a naturally occurring inhibitor of experimental carcinogenesis, was evaluated for its possible inhibitory effect on DNA-adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary mutagen, in female F344 rats. PhIP is a mammary carcinogen in female