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Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

✍ Scribed by Koniaras, Kalli; Cuddihy, Andrew R; Christopoulos, Helen; Hogg, Annette; O'Connell, Matthew J

Book ID: 110066175
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 393 KB
Volume: 20
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1204942

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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh