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Inhibition of cell-mediated cytotoxicity to chemically induced rat tumours by soluble tumour and embryo cell extracts

✍ Scribed by M. Zöller; M. R. Price; R. W. Baldwin

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
761 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

When lymph‐node and spleen cells from rats bearing or immunized against aminoazo dyeinduced rat hepatomas or 3‐methylcholanthreneinduced rat sarcomas were pretreated with 3 m KCl extracts of these tumours, their cytotoxicity for cultured cells from the corresponding tumour was specifically inhibited. In cross‐test combinations of target tumour and tumour‐bearer effector‐cell donor, tumour extracts only inhibited cytotoxic responses when they were derived from the tumour homologous to the target‐cell and not when the extract was from the tumour borne by the effector‐cell donor. One component of the tumour‐bearer cytotoxic response was shown to be directed against tumour‐associated embryonic antigens since soluble extracts of embryos or tumour extracts containing embryonic antigens inhibited tumour‐bearer cell‐mediate cytotoxicity in both specific and cross‐test combinations of target tumour and effector cells. These findings are discussed in relation to tumour antigen expression and the immune responses that these tumour‐associated antigens may evoke in tumour‐bearing rats.

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