## Abstract We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K i
β¦ LIBER β¦
Inhibition of cathepsin K: blocking osteoclast bone resorption and more
β Scribed by Duong, Le T
- Book ID
- 120923271
- Publisher
- Nature Publishing Group
- Year
- 2013
- Weight
- 133 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1940-8692
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## Abstract Osteoclasts are large multinucleated cells responsible for bone resorption. Bone resorption is dependent on the liberation of calcium by acid and protease destruction of the bone matrix by proteinases. The key proteinase produced by the osteoclast is cathepsin K. Targeted knockβdown of