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Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts

✍ Scribed by Ji-Cheon Jeong; Sung-Koo Kang; Cheol-Ho Youn; Chang-Whan Jeong; Hyung-Min Kim; Young-Choon Lee; Young-Chae Chang; Cheorl-Ho Kim


Book ID
116575472
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
242 KB
Volume
3
Category
Article
ISSN
1567-5769

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## Abstract Osteoclasts are large multinucleated cells responsible for bone resorption. Bone resorption is dependent on the liberation of calcium by acid and protease destruction of the bone matrix by proteinases. The key proteinase produced by the osteoclast is cathepsin K. Targeted knock‐down of