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Inhibition of caspase-3 activation by SB 203580, p38 mitogen-activated protein kinase inhibitor in nitric oxide-induced apoptosis of PC-12 cells

✍ Scribed by Krishna Pada Sarker; Masanori Nakata; Isao Kitajima; Toshihiro Nakajima; Ikuro Maruyama


Book ID
111639509
Publisher
Humana Press Inc
Year
2000
Tongue
English
Weight
336 KB
Volume
15
Category
Article
ISSN
0895-8696

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Involvement of caspase-3 and p38 mitogen
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## Abstract Our previous study showed that cobalt chloride (CoCl~2~) could induce PC12 cell apoptosis and that the CoCl~2~‐treated PC12 cells may serve as a simple in vitro model for the study of the mechanism of hypoxia‐linked neuronal disorders. The aim of this study is to elucidate the mechanism