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Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1β-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord

✍ Scribed by Chun-Sung Sung; Zhi-Hong Wen; Wen-Kuei Chang; Kwok-Hon Chan; Shung-Tai Ho; Shen-Kou Tsai; Yi-Chen Chang; Chih-Shung Wong


Book ID
111178995
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
355 KB
Volume
94
Category
Article
ISSN
0022-3042

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## Abstract Cytokine‐induced expression of inducible nitric oxide synthase (iNOS) and concomitant production of nitric oxide (NO) involve activation of mitogen‐activated protein (MAP) kinases and are in most cases mediated by the transcription factor NF‐κB. We investigated the role of p38 MAP kinas