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Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells

✍ Scribed by Sheng-Nan Wu; Hui-Fan Li; Chung-Ren Jan; Ai-Yu Shen

Book ID
118539810
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
232 KB
Volume
38
Category
Article
ISSN
0028-3908

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Polyamines block Ca2+-activated K+channe
Polyamines block Ca2+-activated K+channels in pituitary tumor cells (GH3)
✍ T. Weiger; A. Hermann πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 800 KB

The effects of the natural polyamines, putrescine, spermidine and spermine on single calcium-activated potassium channels from clonal rat pituitary tumor cells (GH3) were studied. Applied to inside-out patches, polyamines were found to reduce the current amplitude and open probability of the channel