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Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines

✍ Scribed by Gu, Ying; Lee, Hsi‐Ming; Golub, Lorne M.; Sorsa, Timo; Konttinen, Yrjö T.; Simon, Sanford R.


Book ID
123621166
Publisher
Informa plc
Year
2005
Tongue
English
Weight
386 KB
Volume
37
Category
Article
ISSN
0785-3890

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Down-regulation of trypsinogen-2 express
✍ Annukka Lukkonen; Timo Sorsa; Tuula Salo; Taina Tervahartiala; Erkki Koivunen; L 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 86 KB

Many types of human tumor express trypsinogen-2, which may be a significant factor in the activation of pro-MMPs and the invasiveness of tumors. Prevention of trypsinogen-2 expression in cancer cells might be of benefit in cancer therapy. We describe here chemicals capable of down-regulating the exp