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Chemically modified tetracyclines inhibit VEGF secretion by breast cancer cell lines

✍ Scribed by Mansi Kothari; Sanford R. Simon

Book ID
116397743
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
474 KB
Volume
35
Category
Article
ISSN
1043-4666

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Down-regulation of trypsinogen-2 express
Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: Association with reduced cancer cell migration
✍ Annukka Lukkonen; Timo Sorsa; Tuula Salo; Taina Tervahartiala; Erkki Koivunen; L πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 86 KB

Many types of human tumor express trypsinogen-2, which may be a significant factor in the activation of pro-MMPs and the invasiveness of tumors. Prevention of trypsinogen-2 expression in cancer cells might be of benefit in cancer therapy. We describe here chemicals capable of down-regulating the exp