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Inhibition of bone collagen synthesis by the tumor promoter phorbol 12-myristate 13-acetate

✍ Scribed by Dr. Jean H.M. Feyen; Donna N. Petersen; Barbara E. Kream


Book ID
112118317
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
583 KB
Volume
3
Category
Article
ISSN
0884-0431

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## Abstract The phorbol esters phorbol 12‐retinoate 13‐acetate (RPA) and 12‐O‐tetradecanoyl phorbol 13‐acetate (TPA) were used to investigate the role of tumor promoters in the control of hormone response in normal and leukemic myeloid celts. RPA and TPA inhibited the binding of [20‐3H]phorbol 12,1