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Control of endogenous cell regulators by the second-stage tumor promoter phorbol-12-retinoate 13-acetate

✍ Scribed by Rabi Simantov; Friedrich Marks; Gerhard Furstenberger; Leo Sachs

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
403 KB
Volume
31
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The phorbol esters phorbol 12‐retinoate 13‐acetate (RPA) and 12‐O‐tetradecanoyl phorbol 13‐acetate (TPA) were used to investigate the role of tumor promoters in the control of hormone response in normal and leukemic myeloid celts. RPA and TPA inhibited the binding of [20‐3H]phorbol 12,13‐dibutyrate to the leukemic cells in a competitive manner with 50% inhibition values of 5.2±l.3 and 1.1±0.6 nM, respectively. RPA, like TPA, enhanced (1) prostaglandin E,‐induced cyclic AMP synthesis, (2) the differentiation of leukemic cells induced by the normal myeloid differentiation‐inducing protein, and (3) the formation of normal myeloid cells colonies induced by the normal myeloid growth‐inducing protein. Both compounds can thus control endogenous cell regulators. Since RPA functions in the second stage of tumor promotion in mouse skin, it is suggested that the control of such endogenous regulators may involve biochemical pathways similar to those that are activated in the second stage of tumor promotion.

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