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Inhibition of Autophagy Enhances Cell Death Induction by 5-Fluorouracil in Human Colon Cancer Cells

✍ Scribed by Huang, Shengbing ;Yang, Zhineng J. ;Sinicrope, Frank A.

Book ID: 122131261
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 39 KB
Volume: 140
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(11)62828-X

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## Abstract Trifluorothymidine (TFT) is part of the oral drug formulation TAS‐102. Both 5‐fluorouracil (5‐FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross‐resistance to 5‐FU. Therefore, we examined whether mechanistic differences in cell death