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Inhibition of apoptosis in familial adenomatous polyposis (FAP) and its modification by sulindac

✍ Scribed by P.J. Pasricha; A. Bedi; A. Rashid; S.R. Hamilton; A.J. Akhtar; K. O'Connor; F.M. Giardiello


Book ID
118880097
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
157 KB
Volume
108
Category
Article
ISSN
0016-5085

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Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua