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Inhibition of Alanyl-Aminopeptidase Suppresses the Activation-Dependent Induction of Glycogen Synthase Kinase-3β (GSK-3β) in Human T Cells

✍ Scribed by Uwe Lendeckel; Beate Scholz; Marco Arndt; Karin Frank; Antje Spiess; Huixiong Chen; Bernard P. Roques; Siegfried Ansorge


Book ID
115585968
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
85 KB
Volume
273
Category
Article
ISSN
0006-291X

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## Abstract Glycogen synthase kinase 3β (GSK3β) activity is regulated by phosphorylation processes and regulates in turn through phosphorylation several proteins, including eukaryotic initiation factor 2B (eIF2B). Serine 9 phosphorylation of GSK3β (pGSK3βSer9), usually promoted by activation of the