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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

✍ Scribed by Meydan, Naftaly; Grunberger, Tom; Dadi, Harjit; Shahar, Michal; Arpaia, Enrico; Lapidot, Zvi; Leeder, J. Steven; Freedman, Melvin; Cohen, Amos; Gazit, Aviv


Book ID
109795172
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
980 KB
Volume
379
Category
Article
ISSN
0028-0836

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In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Fr