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Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia

✍ Scribed by Amos Gaikwad; Cassia L. Rye; Meenakshi Devidas; Nyla A. Heerema; Andrew J. Carroll; Shai Izraeli; Sharon E. Plon; Giuseppe Basso; Andrea Pession; Karen R. Rabin


Book ID
108676159
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
126 KB
Volume
144
Category
Article
ISSN
0007-1048

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In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Fr