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Inhibition of activated protein C by aprotinin and the use of the insolubilized inhibitor for its purification

✍ Scribed by O. Taby; J. Chabbat; M. Steinbuch

Book ID
119037829
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
598 KB
Volume
59
Category
Article
ISSN
0049-3848

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The role of lysines 37-39 (chymotrypsin numbering) in the 37-loop of the serine protease activated protein C (APC) was studied by expressing acidic and neutral recombinant APC (rAPC) mutants. Activity of the APC mutants was assessed using human plasma and plasma-purified and recombinant derivatives