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Specificity of sulfated polysaccharides to accelerate the inhibition of activated protein C by protein C inhibitor

✍ Scribed by Yoshiaki Kazama; Masahiro Niwa; Ryoichi Yamagishi; Kaoru Takahashi; Nobuo Sakuragawa; Takehiko Koide


Book ID
119036986
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
444 KB
Volume
48
Category
Article
ISSN
0049-3848

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Basic residues in the 37-loop of activat
✍ Laura N. Glasscock; Bruce Gerlitz; Scott T. Cooper; Brian W. Grinnell; Frank C. πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 502 KB

The role of lysines 37-39 (chymotrypsin numbering) in the 37-loop of the serine protease activated protein C (APC) was studied by expressing acidic and neutral recombinant APC (rAPC) mutants. Activity of the APC mutants was assessed using human plasma and plasma-purified and recombinant derivatives