Inhibition of acetylcholinesterase by O-(methylcarbamoyl) oximes. Structure-activity relationships
✍ Scribed by Mrlina, Georges; Calmon, Jean Pierre
- Book ID
- 126959444
- Publisher
- American Chemical Society
- Year
- 1980
- Tongue
- English
- Weight
- 398 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0021-8561
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
4-Nitrophenyl-N-substituted carbamates (1) are characterized as pseudosubstrate inhibitors of acetylcholinesterase. The first step is formation of the enzyme-inhibitor tetrahedral intermediate with the inhibition constant (K i ), the second step is formation of the carbamyl enzyme with the carbamyla
## Abstract Organophosphorus pesticides parathion, chlorpyrifos, and malathion inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of intoxication by these AChE inhibito