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Inhibition of acetaminophen oxidation and toxicity by methoxsalen in mice and in humans

✍ Scribed by Kierse, Robert; Jensen, Ute; Helmberger, Hermann; Muth, Gerhard; Rieber, Andrea

Book ID
122093449
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
41 KB
Volume
3
Category
Article
ISSN
0168-8278

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N-Acetyl-DL-penicillamine (IIIb), a structural analog of N-acetyl-L-cysteine (IIIa), did not protect mice from lethal doses of acetaminophen (I), whereas IIIa offered protection. This lack of efficacy of IIIb probably is due to the decreased nucleophilicity of its sulfhydryl group compared to that o