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Inhibition of [3H]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships

✍ Scribed by Jan O. Marcusson; Ulf Norinder; Thomas Högberg; Svante B. Ross

Book ID
115887360
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
546 KB
Volume
215
Category
Article
ISSN
0014-2999

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An analysis of five different datasets of inhibitors of serotonin uptake has yielded quantitative structure/ activity relationships (QSARs) which delineate the role of steric and hydrophobic properties essential for inhibition by phenylethylamine-type analogues.