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Inhibition by glucose of the synthesis of proline from glutamic acid

✍ Scribed by Martin Forbes; M.G. Sevag

Book ID
118839135
Publisher
Elsevier Science
Year
1951
Tongue
English
Weight
545 KB
Volume
31
Category
Article
ISSN
0003-9861

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Two mutant Chinese hamster lung fibroblast lines have been isolated that are resistant to the the toxic proline analog L-azetidine-2-carboxylic acid. The line designated AZCA-1 has 30-fold elevated activity of pyrroline-5-carboxylate synthase and a large increase in the rate of proline production an