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Inhibiting gene expression in vivo by virus-mediated small interfering RNA

✍ Scribed by P. Y. Wang; S. Xie; A. D. Cui; F. Jiao; Z. L. Li; X. Y. Bai; F. Liu

Book ID: 110174629
Publisher: SP MAIK Nauka/Interperiodica
Year: 2008
Tongue: English
Weight: 248 KB
Volume: 42
Category: Article
ISSN: 0026-8933
DOI: 10.1134/s0026893308060083

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## Abstract In order to develop a gene therapy to human cytomegalovirus (HCMV), RNA interference (RNAi) was employed to inhibit the expression of HCMV UL122 gene __in vitro__. Recombinant vector pUL122‐EGFP, which expressed UL122‐EGFP fusion protein, and recombinant vectors psi122‐1, psi122‐2 and p