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Infrared and Raman spectra of N-acetyl-l-amino acid methylamides with aromatic side groups

✍ Scribed by Hiroatsu Matsuura; Kodo Hasegawa; Tatsuo Miyazawa

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
842 KB
Volume
42
Category
Article
ISSN
1386-1425

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✦ Synopsis

Infrared and Raman spectra of N-acetyl+phenylalanine methylamide, N-acetyl-r,-tyrosine methylamide and N-acetyl+tryptophan methylamide, as model compounds of aromatic amino acid residues in proteins, were measured in the solid state and in methanol solutions. Vibrational assignments of the spectra were made by utilizing the deuteration effect and by comparison with the spectra of related compounds which include toluene, p-cresol and 3-methylindole. The amide I, III and IV bands were strong in Raman scattering, but other characteristic amide band8 were illdefined. In the Raman spectra of methanol solutions, only the band8 due to the aromatic side group vibrations were markedly observed, but those due to the peptide backbone vibrations were very weak, suggesting the coexistence of various molecular conformations in solution.

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✍ Jan Hlaváček; Václav Matějka; Petr C̆ársky 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 856 KB

## Abstract φ – ψ maps have been calculated by the MM2(87) potential for the __N__^α^‐acetyl derivatives of Gly, Ala, Val, and Tle methylamides and their __N__^α^‐methyl substituted derivatives to interpret the ^1^H NMR and CD spectra of these compounds. From the critical examination of the availab