Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture
✍ Scribed by Gestwicki, Jason E.; Cairo, Christopher W.; Strong, Laura E.; Oetjen, Karolyn A.; Kiessling, Laura L.
- Book ID
- 118010098
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 504 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We present a model to describe the equilibrium binding properties for the attachment of multivalent ligands to mobile receptors in membranes. The interaction is assumed to be governed by two inherently different association constants. The first of these controls the initial attachment o
In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor (ASGPR), four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro. The results showed that trivalent cluste