𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Influences of meningeal cells on brain development

✍ Scribed by Jobst Sievers; Fritz -Wilhelm Pehlemann; Martin Berry

Book ID
104766980
Publisher
Springer
Year
1986
Tongue
English
Weight
850 KB
Volume
73
Category
Article
ISSN
0028-1042

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✦ Synopsis

Destruction of meningeal cells during brain development results in alterations of the extracellular matrix over the surface of the central nervous system, and a regional disruption of the external glial limiting membrane, associated with a reorganization of the glial scaffold. These changes of the glial organization have repercussions on neuronal migration and aggregation leading to a failure of neurons to segregate into spatially separated layers and lobules. We propose that meningeal cells stabilize the labile outer surface of the brain and the glial scaffold during development by specifically controlling the composition of the extracellular matrix at the interface with glial end-feet.

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