Influence ofCYP2D6genotype and medication on the sparteine metabolic ratio of psychiatric patients
✍ Scribed by P.L. Lohmann; M.L. Rao; M. Ludwig; E.U. Griese; U.M. Zanger; K. Mörike; W. Maier; M. Bagli
- Book ID
- 105923150
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 117 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0031-6970
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Objective The sum of the serum levels of risperidone (RIS) and 9-hydroxyrisperidone (9-OH-RIS), which is the active moiety serum level, could be important for estimating the clinical effects of RIS. However, there have been no consistent results reported about the relationship between cytochrome P45
## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the