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A population pharmacokinetic evaluation of the influence of CYP2D6 genotype on risperidone metabolism in patients with acute episode of schizophrenia

✍ Scribed by Igor Locatelli; Matej Kastelic; Jure Koprivšek; Blanka Kores-Plesničar; Aleš Mrhar; Vita Dolžan; Iztok Grabnar

Book ID
113592340
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
483 KB
Volume
41
Category
Article
ISSN
0928-0987

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Effects of the CYP2D6*10 alleles and co-
Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-dependent drugs on risperidone metabolism in patients with schizophrenia
✍ Tatsuhiko Yagihashi; Masafumi Mizuno; Bun Chino; Yuji Sato; Kei Sakuma; Toru Tak 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 121 KB

## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the